https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Patterns of Relapse in Australian Patients With Clinical Stage 1 Testicular Cancer: Utility of the Australian and New Zealand Urogenital and Prostate Cancer Trials Group Surveillance Recommendations https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53996 Wed 28 Feb 2024 16:39:56 AEDT ]]> Defining reliable disability outcomes in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:22648 Wed 22 May 2019 14:50:34 AEST ]]> Sun exposure across the life course significantly modulates early multiple sclerosis clinical course https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:47544 Wed 22 Mar 2023 15:52:30 AEDT ]]> Cue-induced food seeking after punishment is associated with increased Fos expression in the lateral hypothalamus and basolateral and medial amygdala https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:32928 Wed 17 Nov 2021 16:30:57 AEDT ]]> An emerging role for the mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:14893 Wed 11 Apr 2018 14:56:12 AEST ]]> The role of cocaine- and amphetamine- regulated transcript (CART) and orexin in drug- seeking and addiction-related behaviours https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:14038 Wed 11 Apr 2018 14:55:16 AEST ]]> Workplace-related smoking in New South Wales: extent of bans, public attitudes and relationships with relapse https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:14128 Wed 11 Apr 2018 13:06:16 AEST ]]> Outcome of lower-intensity allogeneic transplantation in non-Hodgkin lymphoma after autologous transplantation failure https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:28486 Wed 11 Apr 2018 12:16:27 AEST ]]> Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:14350 +). The effect of VTA-directed injections of SB-334867 (0 or 3 μg) on locomotor activity was also assessed. Intra-VTA, but not -PVT, SB-334867 dose-dependently attenuated S+-induced reinstatement (3 μg dose, p<0.01). Intra-VTA SB-334867 had no effect on locomotor activity. We conclude that OrxR1 signalling within the VTA, but not the PVT, mediates cue-induced cocaine-seeking behaviour. We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation.]]> Wed 11 Apr 2018 11:48:59 AEST ]]> Molecular correlates of dopamine signalling in addiction vulnerability https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:11414 Wed 11 Apr 2018 10:22:09 AEST ]]> Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:14895 Wed 11 Apr 2018 09:14:41 AEST ]]> Variation within MBP gene predicts disease course in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34728 interaction = 0.05) and relapse (pinteraction = 0.02). Functional prediction analysis showed this variant is the target of many transcription factors and the binding sites of miR-218 and miR-188-3p. Conclusions: Our results provide novel insights into the role of genetic variation within the MBP gene predicting MS clinical course, both directly and by interaction with known environmental MS risk factors.]]> Wed 04 Sep 2019 10:04:21 AEST ]]> Role of ventral subiculum in context-induced relapse to alcohol seeking after punishment-imposed abstinence https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:24562 Wed 02 Mar 2022 14:24:02 AEDT ]]> Multiple Sclerosis Relapses Following Cessation of Fingolimod https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53300 Tue 21 Nov 2023 12:02:22 AEDT ]]> Whole-genome sequencing to differentiate relapse from reinfection in community-onset bacteremic Acinetobacter baumannii pneumonia https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:45198 Acinetobacter baumannii pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3-56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.]]> Tue 14 Nov 2023 14:44:58 AEDT ]]> Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:43091 Tue 13 Sep 2022 12:26:49 AEST ]]> Temporally specific miRNA expression patterns in the dorsal and ventral striatum of addiction-prone rats https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:36090 Thu 17 Mar 2022 14:39:03 AEDT ]]> Telephone-delivered psychosocial interventions targeting key health priorities in adults with a psychotic disorder: systematic review https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:35335 Thu 17 Mar 2022 14:34:32 AEDT ]]> Characterizing changes in the orexin system in models of neuropsychiatric disease https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:27474 Thu 13 Sep 2018 16:54:06 AEST ]]> Molecular and phosphoproteomic characterisation of FLT3 inhibitor resistance in acute myeloid leukaemia https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:55549 Thu 06 Jun 2024 09:53:01 AEST ]]> Predictors of relapse and disability progression in MS patients who discontinue disease-modifying therapy https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:41240 Sat 30 Jul 2022 12:19:30 AEST ]]> Propensity to 'relapse' following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:15635 +) or drug non-availability (S−). Once a stable level of responding was reached, lever pressing was extinguished. Animals were then tested for reinstatement and sacrificed immediately following the presentation of either the S− or S+ discriminative stimuli, and Fos-protein expression was assessed in thalamic and epithalamic regions. Interestingly, significant variation was observed in reinstatement behaviour, allowing a comparison between high-reinstating (HR), low-reinstating (LR) and control animals. Compared with LR animals, HR animals exhibited increased Fos-protein expression in the PVT, intermediodorsal thalamus and the medial and lateral divisions of the habenula. Our data provide evidence that activation of thalamic and epithalamic nuclei is associated with propensity to reinstate to cocaine-seeking elicited by drug-related cues. We also build upon existing data highlighting the importance of the PVT in reinstatement behaviour.]]> Sat 24 Mar 2018 08:23:44 AEDT ]]> Treatment of children with poor risk solid tumors by further escalation of the VETOPEC regimen including very high-dose cyclophosphamide and peripheral stem cell support: an Australian and New Zealand Children's Hematology and Oncology Group Study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:15288 Sat 24 Mar 2018 08:21:53 AEDT ]]> Hyper-peptiduria in mulitple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:11093 Sat 24 Mar 2018 08:12:04 AEDT ]]> Influence of age and histology on outcome in adult non-hodgkin lymphoma patients undergoing autologous hematopoietic cell transplantation (HCT): A report from The Center For International Blood & Marrow Transplant Research (CIBMTR) https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:5007 Sat 24 Mar 2018 07:44:14 AEDT ]]> Risk of early relapse following the switch from injectables to oral agents for multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:30017 Sat 24 Mar 2018 07:28:49 AEDT ]]> Risk factors for relapse or persistence of bacteraemia caused by Enterobacter spp.: a case-control study https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:32931 Enterobacter spp. possess chromosomal AmpC beta-lactamases that may be expressed at high levels. Previous studies have demonstrated a risk of relapsed bacteraemia following therapy with third generation cephalosporins (3GCs). What additional factors predict microbiological failure in Enterobacter bacteraemia is unclear. We aimed to determine factors associated with microbiological failure in Enterobacter bacteraemia. Methods: We retrospectively identified cases of bacteraemia caused by Enterobacter spp. occurring in four hospitals. Using a case-control design, we determined clinical risk factors for persistence or relapse defined as repeated positive blood cultures collected between 72 hours and up to 28 days post initial positive blood culture. Results: During the study period a total of 922 bacteraemia events caused by Enterobacter spp. in adults were identified. The overall risk of relapsed or persisting bacteraemia at 28 days was low (31 of 922, 3.4%), with only 2 patients experiencing emergent resistance to 3GCs. A total of 159 patients were included in the case-control study. Using multivariate logistic regression, independent predictors for relapse were a line-associated source of infection (OR 3.87; 95% CI 1.56-9.60, p = 0.004) and the presence of immunosuppression (OR 2.70; 95% CI 1.14-6.44, p = 0.02). On univariate analysis definitive therapy with a broad-spectrum beta-lactam-beta-lactamase inhibitor (BLBLI, e.g. piperacillin-tazobactam) was not associated with relapse (OR 1.83; 95% CI 0.64-5.21, p = 0.26) although the proportion of patients receiving a BLBLI as definitive therapy was relatively small (21/159, 13.2%). Conclusions: The risk of relapsed or persistent Enterobacter bacteraemia appears to be low in Australia. A line-associated source of infection and immunocompromise were significant independent predictors for relapse. Larger, preferably randomized, studies are needed to address whether BLBLIs represent an effective carbapenem-sparing option for Enterobacter bacteraemia.]]> Mon 23 Sep 2019 12:28:05 AEST ]]> Comparative effectiveness of cladribine tablets versus other oral disease-modifying treatments for multiple sclerosis: Results from MSBase registry https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51882 Fri 22 Sep 2023 09:08:11 AEST ]]> Safety of exercise training in multiple sclerosis: An updated systematic review and meta-analysis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:54950 Fri 22 Mar 2024 15:28:58 AEDT ]]> Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42294 Fri 19 Aug 2022 14:58:38 AEST ]]> Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51340 Fri 01 Sep 2023 13:35:50 AEST ]]> Efficacy and safety of monoclonal antibody therapy in patients with neuromyelitis optica spectrum disorder: A systematic review and network meta-analysis https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53516 Fri 01 Dec 2023 11:06:04 AEDT ]]>